Interaction Between Amorolfine and Voriconazole Against Fusarium species

Fusarium species represent a range of fungal pathogens capable causing diverse mycotic diseases. Relative to antibacterial drugs, few effective antifungal agents have been developed date, and all are subject significant limitations. As such, there is an urgent need design novel treatments for infections caused by spp. Herein, 15 clinical isolates, including 5 oxysporum 10 solani strains, were analyzed explore the relative inhibitory effects different combinations amorolfine (AMO) voriconazole (VOR) on growth these pathogens. These analyses conducted measuring minimal concentration (MIC) values in broth microdilution assay using vivo model Fusarium-infected Galleria mellonella. experiments revealed that isolation, AMO VOR exhibited MIC ranging from 4 16 ?g/mL 2 8 ?g/mL, respectively. However, fell 1–2 0.5–2 respectively, when administered combination with one another, exhibiting synergistic activity against 73.3% strains. Subsequent G. mellonella further confirmed + treatment was associated significantly improved larval survival following infection. Together, results serve as first published evidence demonstrating exhibit spp., indicating they may approach disease treatment.